Investigating immune responses in severe hemophilia A across generations
A Severe Hemophilia A Intergenerational Cohort Research Program for the Study of Factor VIII Immunogenicity
This study is looking for mothers and their babies with severe hemophilia A to learn how babies' immune systems respond to a treatment called Factor VIII during their first two years of life, so we can better understand and help manage this condition.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-10916298 on NIH RePORTER |
What this research studies
This research program aims to create a cohort of mother-baby pairs to study how immune responses to Factor VIII develop in infants with severe hemophilia A. By following these pairs over the first two years of life, the program will collect valuable data and biological samples to understand the factors that influence the development of FVIII inhibitors. The research will also establish a resource portal to share findings and samples with the broader research community, enhancing collaboration and knowledge in this area.
Who could benefit from this research
Good fit: Ideal candidates for this research include mothers who are genetic carriers of severe hemophilia A and their infants diagnosed with the condition.
Not a fit: Patients who do not have severe hemophilia A or are not part of a mother-baby pair may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and management of immune responses in hemophilia A, potentially reducing complications for affected patients.
How similar studies have performed: Previous research has shown promise in studying immune responses in hemophilia, but this specific intergenerational approach is relatively novel.
Where this research is happening
Seattle, United States
- University of Washington — Seattle, United States (Active)
Researchers
- Principal investigator: Johnsen, Jill Marie — University of Washington
- Study coordinator: Johnsen, Jill Marie
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.