Investigating immune responses in persistent fungal and bacterial infections
Official title: Human Immunomics & Trained Immunity in Persistent Candidemia
Funded at Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center · NIH-11091672 · Data updated 2026-11-12
This study is looking at how the immune system reacts to tough infections like candidiasis and MRSA by examining blood samples from patients, with the hope of finding better ways to treat these stubborn infections.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center NIH-funded |
| Lab location | 1 site (Torrance, United States) |
| Project start | August 10, 2023 |
| Project end | May 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $430,558 |
| NIH project number | 5U19AI172713-03 |
| Project ID | NIH-11091672 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include patients with persistent candidemia or MRSA infections who are undergoing treatment.
✕Less likely to help
Patients with infections that are not caused by HDC or MRSA may not benefit from this research.
What this research studies
This research focuses on understanding how the immune system responds to persistent infections caused by hematologic disseminated candidiasis (HDC) and methicillin-resistant Staphylococcus aureus (MRSA). By analyzing patient blood samples and using advanced multi-omics techniques, the study aims to create detailed immune profiles and explore the interactions between innate and adaptive immune responses. The goal is to uncover the mechanisms that lead to persistent infections despite existing treatments, which could help in developing more effective therapies.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies for patients suffering from severe fungal and bacterial infections.
How similar studies have gone: Previous research has shown promise in understanding immune responses to infections, but this approach is innovative and aims to provide new insights into persistent infections.
Where this research is happening
-
Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
Torrance, United States Active
Researchers
- Principal investigator: Reed, Elaine F — Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
- Study coordinator: Reed, Elaine F
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.