Investigating immune responses in neuroblastoma using the cGAS-STING pathway
cGAS-STING and therapeutic immune responses in neuroblastoma
This study is looking at how to make immunotherapy better for kids with neuroblastoma by understanding a specific pathway in the immune system, and it will help train a doctor to find new ways to boost the body's fight against this cancer.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Children's Hosp of Philadelphia NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-10902025 on NIH RePORTER |
What this research studies
This research aims to enhance immunotherapy for pediatric neuroblastoma by exploring the cGAS-STING inflammatory sensing pathway. The project involves training a pediatric oncologist to develop skills in studying how this pathway can be manipulated to improve immune responses against neuroblastoma cells. Using advanced techniques, including immunocompetent mouse models, the research will analyze the tumor immune microenvironment to identify effective therapeutic strategies. The collaboration with leading experts and institutions will provide a robust framework for this innovative approach.
Who could benefit from this research
Good fit: Ideal candidates for this research are children diagnosed with neuroblastoma, particularly those with the mesenchymal state of the tumor.
Not a fit: Patients with neuroblastoma who are not eligible for immunotherapy or those with other unrelated conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective immunotherapy options for children with neuroblastoma.
How similar studies have performed: Previous research has shown promise in utilizing similar immune-targeting approaches in cancer treatment, indicating potential for success in this novel application.
Where this research is happening
Philadelphia, United States
- Children's Hosp of Philadelphia — Philadelphia, United States (Active)
Researchers
- Principal investigator: Wolpaw, Adam J — Children's Hosp of Philadelphia
- Study coordinator: Wolpaw, Adam J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.