Investigating immune responses in melanoma using mouse models and tissue samples
Core 1: Mouse Model and Tissue Biobank Core
['FUNDING_OTHER'] · INSTITUTE FOR SYSTEMS BIOLOGY · NIH-10916314
This study is looking at how combining certain cancer treatments can help kids with melanoma feel better and respond more effectively to their therapies, using tests in mice and samples from patients to find the best ways to fight the disease.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | INSTITUTE FOR SYSTEMS BIOLOGY (nih funded) |
| Locations | 1 site (SEATTLE, UNITED STATES) |
| Trial ID | NIH-10916314 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding how different therapies, particularly a combination of immune checkpoint inhibitors and targeted therapies, can improve treatment outcomes for children with melanoma. By utilizing mouse models and clinical tissue samples, the project aims to analyze the tumor immune microenvironment and how it responds to various treatments. The goal is to identify effective strategies to overcome resistance to therapies and enhance the effectiveness of existing treatments. Patients may benefit from insights gained through this research, which could lead to improved therapeutic approaches for melanoma.
Who could benefit from this research
Good fit: Ideal candidates for this research are children aged 0-11 years who are diagnosed with BRAFV600MUT melanoma or other related conditions.
Not a fit: Patients with melanoma who do not have the BRAFV600MUT mutation or are outside the age range of 0-11 years may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatment strategies for melanoma in children, potentially improving survival rates and quality of life.
How similar studies have performed: Other research has shown promise in using similar combination therapies for melanoma, indicating potential for success in this approach.
Where this research is happening
SEATTLE, UNITED STATES
- INSTITUTE FOR SYSTEMS BIOLOGY — SEATTLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LO, ROGER S — INSTITUTE FOR SYSTEMS BIOLOGY
- Study coordinator: LO, ROGER S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.