Investigating immune responses in gum disease
Mechanistic probes to study the immune response in periodontal disease
['FUNDING_R01'] · MEDICAL UNIVERSITY OF SOUTH CAROLINA · NIH-10817136
This study is looking at how the immune system reacts to gum disease and aims to find new ways to help manage it better by focusing on certain enzymes that cause inflammation and bone loss, which could lead to improved treatments for people dealing with this condition.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MEDICAL UNIVERSITY OF SOUTH CAROLINA (nih funded) |
| Locations | 1 site (CHARLESTON, UNITED STATES) |
| Trial ID | NIH-10817136 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding how the immune system responds to periodontal disease, which affects a significant portion of adults in the U.S. It explores the roles of specific enzymes that regulate inflammation and bone loss associated with this condition. By developing chemical probes that target these enzymes, the research aims to uncover the underlying mechanisms of tissue damage and inflammation in periodontal disease. Patients may benefit from new treatment strategies that more effectively manage their immune response.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults suffering from periodontal disease, particularly those experiencing significant inflammation and bone loss.
Not a fit: Patients without periodontal disease or those with other unrelated health conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments that better control inflammation and bone loss in patients with periodontal disease.
How similar studies have performed: Previous research has shown promise in targeting immune responses in other inflammatory diseases, suggesting potential for success in this novel approach to periodontal disease.
Where this research is happening
CHARLESTON, UNITED STATES
- MEDICAL UNIVERSITY OF SOUTH CAROLINA — CHARLESTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: PETERSON, YURI KARL — MEDICAL UNIVERSITY OF SOUTH CAROLINA
- Study coordinator: PETERSON, YURI KARL
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Connective Tissue Disorder, Connective Tissue Diseases