Investigating immune responses in eosinophilic gastrointestinal diseases
Official title: Relationship of Immune Responses to Clinical Phenotype and Familial Risk in Eosinophilic Gastroenteritis
Funded at University of Utah · NIH-10907796 · Data updated 2026-11-12
This study is looking at how the immune system works in people with eosinophilic gastrointestinal diseases, like eosinophilic gastroenteritis and eosinophilic esophagitis, to help doctors better understand and diagnose these conditions, especially for those who might be at risk.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Utah NIH-funded |
| Lab location | 1 site (Salt Lake City, United States) |
| Project start | August 15, 2023 |
| Project end | July 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $192,500 |
| NIH project number | 5R21AI173627-02 |
| Project ID | NIH-10907796 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals experiencing gastrointestinal symptoms such as abdominal pain and diarrhea, particularly those with a family history of eosinophilic disorders.
✕Less likely to help
Patients with eosinophilic gastrointestinal diseases who do not have a family history or those with unrelated gastrointestinal conditions may not benefit from this research.
What this research studies
This research focuses on understanding the immune responses associated with eosinophilic gastrointestinal diseases, particularly eosinophilic gastroenteritis (EGE) and its relationship with eosinophilic esophagitis (EoE). The study aims to identify specific immune signatures that could help differentiate between patients with EGE and those with concurrent EoE, as well as predict eosinophil counts in high-risk individuals. By analyzing tissue samples and eosinophil levels, the research seeks to improve diagnosis and recognition of these often-misdiagnosed conditions, which can lead to significant gastrointestinal symptoms.
Why it matters
Potential benefit: If successful, this research could lead to earlier and more accurate diagnoses for patients suffering from eosinophilic gastrointestinal diseases, improving their treatment outcomes.
How similar studies have gone: Previous research has shown promise in identifying immune signatures in similar eosinophilic conditions, suggesting that this approach may yield valuable insights.
Where this research is happening
-
University of Utah
Salt Lake City, United States Active
Researchers
- Principal investigator: Peterson, Kathryn a — University of Utah
- Study coordinator: Peterson, Kathryn a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.