Investigating immune responses in children with burn injuries
Pathologic Myeloid Activation in Pediatric Burn Injury
This study is looking at how burn injuries impact the immune system in young children under 5, so we can find better ways to help them avoid infections and other problems after a burn.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project ID | NIH-10673601 on NIH RePORTER |
What this research studies
This research focuses on understanding how burn injuries affect the immune system in children, particularly those under 5 years old. It aims to identify specific immune dysfunctions that occur after a burn injury, which may lead to complications such as infections and organ dysfunction. By studying the immune responses in pediatric patients, the research seeks to develop tailored treatment strategies that are more effective than current methods, which often rely on adult data. The approach includes analyzing the presence of certain immune cells that may contribute to these complications.
Who could benefit from this research
Good fit: Ideal candidates for this research are children under 5 years old who have sustained burn injuries.
Not a fit: Patients who are older than 21 years or those who have not experienced a burn injury may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment protocols for young burn victims, reducing their risk of severe complications and enhancing recovery.
How similar studies have performed: Previous research has shown that understanding age-specific immune responses can lead to better treatment outcomes in pediatric populations, indicating potential success for this approach.
Where this research is happening
Gainesville, United States
- University of Florida — Gainesville, United States (Active)
Researchers
- Principal investigator: Larson, Shawn David — University of Florida
- Study coordinator: Larson, Shawn David
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.