Investigating immune responses in childhood cancers using specific RNA markers.
Childhood high-risk sarcoma derived human satellite (HSAT) and endogenous retroviral (ERV) RNAs in systemic immunosuppression and inflammation
['FUNDING_OTHER'] · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · NIH-10401129
This study is looking at how specific RNA markers in childhood sarcomas can help boost the immune system's fight against cancer, with the goal of creating better treatments for kids battling these types of tumors.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | RESEARCH INST NATIONWIDE CHILDREN'S HOSP (nih funded) |
| Locations | 1 site (COLUMBUS, UNITED STATES) |
| Trial ID | NIH-10401129 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding how certain RNA markers related to childhood high-risk sarcomas can influence the immune system's ability to fight cancer. By exploring the roles of human satellite and endogenous retroviral RNAs, the study aims to enhance the effectiveness of immunotherapies for pediatric cancers. The approach includes identifying barriers to using natural killer (NK) cells and CAR-NK cells as treatments, and improving immunotherapy by targeting suppressive immune cells. Patients may benefit from novel therapies that could improve their response to treatment.
Who could benefit from this research
Good fit: Ideal candidates for this research are children diagnosed with high-risk sarcomas or other pediatric cancers.
Not a fit: Patients with non-cancerous conditions or those not diagnosed with high-risk pediatric cancers may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective immunotherapies for children with high-risk cancers.
How similar studies have performed: Previous research has shown promise in utilizing immunotherapy approaches for pediatric cancers, indicating potential for success in this area.
Where this research is happening
COLUMBUS, UNITED STATES
- RESEARCH INST NATIONWIDE CHILDREN'S HOSP — COLUMBUS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CRIPE, TIMOTHY P — RESEARCH INST NATIONWIDE CHILDREN'S HOSP
- Study coordinator: CRIPE, TIMOTHY P
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancers, neoplasm/cancer