Investigating immune responses in cancer treatment using novel therapies.
Center for Cancer Immunology and Immunotherapy (CCII).
This study is looking at how certain immune treatments can help people with melanoma by examining blood and tumor samples to find clues that show who might respond best to these therapies, with the hope of making cancer treatment more effective for everyone.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Louisville NIH-funded |
| Lab location | 1 site (Louisville, United States) |
| Project ID | NIH-11045959 on NIH RePORTER |
What this research studies
This research focuses on understanding how immunotherapies, particularly immune checkpoint inhibitors and tumor-infiltrating lymphocyte therapies, can improve cancer treatment outcomes. By analyzing blood and tumor tissue samples from melanoma patients, the study aims to identify immune profiles and biomarkers that predict treatment responses. The approach is multi-omic and data-driven, allowing for a comprehensive characterization of the immune system's role in cancer therapy. The ultimate goal is to enhance the effectiveness of immunotherapies and develop better treatment strategies for patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are melanoma patients who are receiving or have received immunotherapy treatments.
Not a fit: Patients with cancers that are not melanoma or those who have not undergone immunotherapy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective cancer treatments tailored to individual patients' immune profiles.
How similar studies have performed: Previous research has shown promising results in using immunotherapy approaches to improve cancer treatment outcomes, indicating that this study builds on established concepts.
Where this research is happening
Louisville, United States
- University of Louisville — Louisville, United States (Active)
Researchers
- Principal investigator: Yan, Jun — University of Louisville
- Study coordinator: Yan, Jun
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.