Investigating immune responses and blood clotting issues in COVID-19 patients
Official title: Caspr/11-dependent immunothrombosis and neuroinflammation during SARS-CoV-2 infection
Funded at Ohio State University · NIH-11072977 · Data updated 2026-11-12
This study is looking at how the immune system affects blood clots and inflammation in the brain and lungs during COVID-19, especially for those dealing with long COVID symptoms, and it hopes to find new treatments to help manage these ongoing issues.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project start | April 10, 2024 |
| Project end | March 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $429,216 |
| NIH project number | 5P01AI175399-02 |
| Project ID | NIH-11072977 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals who have recovered from COVID-19 but are experiencing lingering symptoms such as brain fog or other neurological issues.
✕Less likely to help
Patients who have not been infected with SARS-CoV-2 or those without any post-viral symptoms may not benefit from this research.
What this research studies
This research focuses on understanding how the immune system contributes to blood clot formation and inflammation in the brain and lungs during SARS-CoV-2 infection. It aims to explore the mechanisms behind long COVID symptoms, particularly the role of thrombi and cytokine storms. By collaborating with other projects, the research will also test potential inhibitors that could lead to new treatments. The findings may help identify therapeutic targets for managing long-term effects of COVID-19.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for long COVID and improve the quality of life for affected patients.
How similar studies have gone: Other research has shown promising results in understanding the immune response and thrombus formation in COVID-19, indicating that this approach has potential for success.
Where this research is happening
-
Ohio State University
Columbus, United States Active
Researchers
- Principal investigator: Amer, Amal O — Ohio State University
- Study coordinator: Amer, Amal O
Related research
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.