Investigating immune responses after brain injury in newborns
Official title: Project 3: Albayram
Funded at Medical University of South Carolina · NIH-11049140 · Data updated 2026-11-12
This study is looking at how the immune system reacts after brain injuries in newborns and how that might affect their brain development and behavior later on, using mice to find ways to help reduce these problems.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Medical University of South Carolina NIH-funded |
| Lab location | 1 site (Charleston, United States) |
| Project start | April 1, 2023 |
| Project end | February 29, 2028 |
| Funding year | 2025 |
| Award (this year) | $226,500 |
| NIH project number | 5P20GM148302-03 |
| Project ID | NIH-11049140 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are newborns who have experienced germinal matrix hemorrhage or similar brain injuries.
✕Less likely to help
Patients who have not experienced brain injuries or are outside the neonatal age range may not benefit from this research.
What this research studies
This research focuses on understanding how abnormal immune activity following brain injuries in newborns affects brain development and leads to long-term behavioral issues. The study uses a mouse model to explore the role of complement proteins in neuroinflammation after germinal matrix hemorrhage, a common type of brain injury in premature infants. By examining how these immune responses impact brain function and behavior, the research aims to identify potential therapeutic strategies to reduce the negative effects of such injuries.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve outcomes for infants who suffer from brain injuries.
How similar studies have gone: Previous research has shown promise in understanding immune responses in brain injuries, but this specific approach focusing on complement proteins is relatively novel.
Where this research is happening
-
Medical University of South Carolina
Charleston, United States Active
Researchers
- Principal investigator: Albayram, Onder — Medical University of South Carolina
- Study coordinator: Albayram, Onder
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.