Investigating immune pathways in breast cancers with chromosomal instability
Targeting innate immune pathways in breast cancers with chromosomal instability
This study is looking at how some breast cancers can avoid being attacked by the immune system and aims to find new ways to help improve treatments for patients with metastatic breast cancer.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sloan-Kettering Inst Can Research NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10902113 on NIH RePORTER |
What this research studies
This research focuses on understanding how certain breast cancers, particularly those that have chromosomal instability, evade the body's immune response. It explores the role of chronic inflammatory signaling in these cancer cells and how they manipulate immune pathways to survive. By studying the mechanisms of immune evasion, the research aims to identify potential targets for new therapies that could enhance the effectiveness of existing treatments. Patients may benefit from insights that could lead to more effective strategies for managing metastatic breast cancer.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with metastatic breast cancer exhibiting chromosomal instability.
Not a fit: Patients with early-stage breast cancer or those without chromosomal instability may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatment options that improve outcomes for patients with metastatic breast cancer.
How similar studies have performed: Other research has shown promise in targeting immune pathways in cancer, suggesting that this approach could lead to significant advancements in treatment.
Where this research is happening
New York, United States
- Sloan-Kettering Inst Can Research — New York, United States (Active)
Researchers
- Principal investigator: Bakhoum, Samuel F — Sloan-Kettering Inst Can Research
- Study coordinator: Bakhoum, Samuel F
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.