Investigating immune memory in non-allergic asthma
ILC2 memory in asthma
This study is looking into how certain environmental factors can trigger asthma symptoms in adults who don't have allergies, using mice to learn more about how the immune system remembers these triggers, which could help develop better treatments for asthma.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | National Jewish Health NIH-funded |
| Lab location | 1 site (Denver, United States) |
| Project ID | NIH-10896150 on NIH RePORTER |
What this research studies
This research focuses on understanding the mechanisms behind non-allergic asthma, which affects a significant portion of adults with asthma. By using a mouse model, the study examines how repeated exposure to certain environmental factors can lead to immune memory in specific immune cells. The researchers aim to identify how this memory contributes to asthma symptoms and inflammation, potentially leading to new treatment strategies. The approach includes analyzing immune responses and gene activity related to asthma.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults aged 21 and older who suffer from non-allergic asthma.
Not a fit: Patients with allergic asthma or those under 21 years old may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that better manage or prevent non-allergic asthma symptoms.
How similar studies have performed: Previous research has shown promising results in understanding immune responses in asthma, but this specific approach to studying ILC memory is relatively novel.
Where this research is happening
Denver, United States
- National Jewish Health — Denver, United States (Active)
Researchers
- Principal investigator: Alam, Rafeul — National Jewish Health
- Study coordinator: Alam, Rafeul
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.