Investigating immune mechanisms during pregnancy and their impact on complications
Innate Immune Mechanisms at the Maternal-Fetal Interface in Normal and Superovulatory Pregnancy
This study is looking at how certain immune cells in pregnant women can affect the success of pregnancies, especially for those who have experienced repeated pregnancy loss or complications, to help improve outcomes for moms and babies.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rutgers Biomedical and Health Sciences NIH-funded |
| Lab location | 1 site (Newark, UNITED STATES) |
| Project ID | NIH-10681406 on NIH RePORTER |
What this research studies
This research explores how immune cells at the maternal-fetal interface influence pregnancy outcomes, particularly in cases of recurrent pregnancy loss and other complications. By examining the roles of specific immune cells, such as uterine natural killer cells and macrophages, the study aims to understand how these cells contribute to healthy placentation and the risks associated with in vitro fertilization. The research utilizes advanced molecular techniques to uncover the signaling pathways involved, particularly focusing on the IL-33 cytokine and its effects on immune cell function during pregnancy.
Who could benefit from this research
Good fit: Ideal candidates for this research include women experiencing recurrent pregnancy loss or complications related to pregnancy, particularly those undergoing in vitro fertilization.
Not a fit: Patients who are not experiencing pregnancy complications or who are not planning to conceive may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and management of pregnancy complications, potentially reducing the rates of recurrent miscarriage and other related disorders.
How similar studies have performed: Previous research has shown promising results in understanding immune mechanisms in pregnancy, suggesting that this approach could yield valuable insights.
Where this research is happening
Newark, UNITED STATES
- Rutgers Biomedical and Health Sciences — Newark, United States (Active)
Researchers
- Principal investigator: Douglas, Nataki C — Rutgers Biomedical and Health Sciences
- Study coordinator: Douglas, Nataki C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.