Investigating immune checkpoints in the brain related to HIV and cognitive disorders
Official title: Immune checkpoints in the CNS and HIV-associated neurocognitive disorder
Funded at Indiana University Indianapolis · NIH-10889463 · Data updated 2026-11-12
This study is looking at how certain immune markers in the brain might affect thinking and memory problems in people with HIV, and it hopes to find clues that could help improve treatment for these issues.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Indiana University Indianapolis NIH-funded |
| Lab location | 1 site (Indianapolis, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $823,691 |
| NIH project number | 1R56NS129438-01A1 |
| Project ID | NIH-10889463 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals living with HIV, particularly those experiencing cognitive difficulties.
✕Less likely to help
Patients who are HIV-negative or do not have cognitive impairments related to HIV may not benefit from this research.
What this research studies
This research explores how immune checkpoints in the central nervous system (CNS) may influence cognitive disorders associated with HIV. By analyzing cerebrospinal fluid samples from individuals with and without HIV-associated neurocognitive disorder (HAND), the study aims to identify specific immune markers that could indicate disease severity or progression. The researchers utilize advanced immunoassays to quantify various soluble immune checkpoints, providing insights into their roles in brain health and disease. This could lead to new therapeutic strategies for managing cognitive impairments in people living with HIV.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostic tools and treatments for cognitive disorders in individuals living with HIV.
How similar studies have gone: Previous research has shown promise in understanding immune checkpoints in other contexts, but this specific investigation into the CNS and HIV-related cognitive disorders is relatively novel.
Where this research is happening
-
Indiana University Indianapolis
Indianapolis, United States Active
Researchers
- Principal investigator: Yu, Qigui a. — Indiana University Indianapolis
- Study coordinator: Yu, Qigui a.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.