Investigating immune cells in lung transplant failure
Tissue resident memory T cells and chronic lung allograft dysfunction
['FUNDING_R01'] · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · NIH-11091657
This study is looking at how certain immune cells in the lungs affect lung transplant patients who are experiencing problems, with the goal of finding ways to improve their treatment and help them stay healthy longer.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF PITTSBURGH AT PITTSBURGH (nih funded) |
| Locations | 1 site (PITTSBURGH, UNITED STATES) |
| Trial ID | NIH-11091657 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the role of tissue resident memory T cells in chronic lung allograft dysfunction (CLAD), a serious complication that affects lung transplant recipients. The study aims to determine how these immune cells contribute to lung allograft failure and how they interact with their environment. By examining the effects of commonly used immunosuppressants on these T cells, the research seeks to improve long-term outcomes for lung transplant patients. Patients may benefit from insights that could lead to better management strategies for preventing CLAD.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have undergone lung transplantation and are at risk for chronic lung allograft dysfunction.
Not a fit: Patients who have not received a lung transplant or those with other unrelated chronic lung conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments that enhance the longevity and function of lung transplants.
How similar studies have performed: Previous research has shown that understanding immune responses in transplant settings can lead to significant advancements in managing transplant rejection, indicating potential success for this approach.
Where this research is happening
PITTSBURGH, UNITED STATES
- UNIVERSITY OF PITTSBURGH AT PITTSBURGH — PITTSBURGH, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SNYDER, MARK EUGENE — UNIVERSITY OF PITTSBURGH AT PITTSBURGH
- Study coordinator: SNYDER, MARK EUGENE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.