Investigating immune cells in lung transplant failure
Official title: Tissue resident memory T cells and chronic lung allograft dysfunction
Funded at University of Pittsburgh at Pittsburgh · NIH-11091657 · Data updated 2026-11-12
This study is looking at how certain immune cells in the lungs affect lung transplant patients who are experiencing problems, with the goal of finding ways to improve their treatment and help them stay healthy longer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project start | July 20, 2023 |
| Project end | April 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $743,120 |
| NIH project number | 5R01HL167901-03 |
| Project ID | NIH-11091657 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have undergone lung transplantation and are at risk for chronic lung allograft dysfunction.
✕Less likely to help
Patients who have not received a lung transplant or those with other unrelated chronic lung conditions may not benefit from this research.
What this research studies
This research focuses on understanding the role of tissue resident memory T cells in chronic lung allograft dysfunction (CLAD), a serious complication that affects lung transplant recipients. The study aims to determine how these immune cells contribute to lung allograft failure and how they interact with their environment. By examining the effects of commonly used immunosuppressants on these T cells, the research seeks to improve long-term outcomes for lung transplant patients. Patients may benefit from insights that could lead to better management strategies for preventing CLAD.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments that enhance the longevity and function of lung transplants.
How similar studies have gone: Previous research has shown that understanding immune responses in transplant settings can lead to significant advancements in managing transplant rejection, indicating potential success for this approach.
Where this research is happening
-
University of Pittsburgh at Pittsburgh
Pittsburgh, United States Active
Researchers
- Principal investigator: Snyder, Mark Eugene — University of Pittsburgh at Pittsburgh
- Study coordinator: Snyder, Mark Eugene
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.