Investigating immune cells in heart disease
Vascular macrophages and T cells in atherosclerosis
This study is looking at how certain immune cells affect heart disease caused by atherosclerosis, and it’s testing new vaccines that might help the immune system fight this condition, so people can have better treatment options in the future.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Augusta University NIH-funded |
| Lab location | 1 site (Augusta, United States) |
| Project ID | NIH-11078192 on NIH RePORTER |
What this research studies
This research focuses on understanding how specific immune cells, particularly T cells and macrophages, contribute to the development of atherosclerosis, a condition that can lead to heart disease. The researchers are exploring the potential of using vaccines that target a protein called apolipoprotein B (ApoB) to stimulate the immune system to fight against atherosclerosis. By isolating and studying these immune cells in both mice and humans, they aim to uncover mechanisms that could lead to new treatments. The study involves testing various vaccine formulations and observing their effects on immune responses and atherosclerosis progression.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals at risk for atherosclerosis or those with existing cardiovascular conditions.
Not a fit: Patients with conditions unrelated to atherosclerosis or those who do not have immune system involvement in their cardiovascular disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative immunotherapies that prevent or treat atherosclerosis, potentially reducing the risk of heart disease.
How similar studies have performed: Previous research has shown promise in using immune modulation for treating atherosclerosis, suggesting that this approach could be a viable avenue for further exploration.
Where this research is happening
Augusta, United States
- Augusta University — Augusta, United States (Active)
Researchers
- Principal investigator: Ley, Klaus F. — Augusta University
- Study coordinator: Ley, Klaus F.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.