Investigating immune cells in Crohn's disease
CD4+ Tissue resident memory T-cells in Crohnâs Disease
['FUNDING_CAREER'] · UNIVERSITY OF MICHIGAN AT ANN ARBOR · NIH-10896984
This study is looking at how certain immune cells in the gut, called CD4+ tissue resident memory T-cells, react to changes in the bacteria living in our intestines, which could help us find better ways to treat Crohn's disease.
Quick facts
| Phase | ['FUNDING_CAREER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF MICHIGAN AT ANN ARBOR (nih funded) |
| Locations | 1 site (ANN ARBOR, UNITED STATES) |
| Trial ID | NIH-10896984 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the role of CD4+ tissue resident memory T-cells in Crohn's disease, a chronic inflammatory condition affecting the intestines. The study aims to characterize how these immune cells respond to changes in gut microbiota, which may contribute to the disease's progression. By examining the pathways and behaviors of these T-cells, researchers hope to identify new therapeutic targets and biomarkers that could improve treatment outcomes for patients. The approach involves advanced techniques to analyze immune cell behavior in the intestinal environment.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Crohn's disease who are experiencing ongoing symptoms despite current treatments.
Not a fit: Patients with Crohn's disease who are in remission or those with other forms of inflammatory bowel disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies and better management strategies for patients with Crohn's disease.
How similar studies have performed: Previous research has shown promising results in understanding immune responses in inflammatory bowel diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
ANN ARBOR, UNITED STATES
- UNIVERSITY OF MICHIGAN AT ANN ARBOR — ANN ARBOR, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BISHU, SHRINIVAS — UNIVERSITY OF MICHIGAN AT ANN ARBOR
- Study coordinator: BISHU, SHRINIVAS
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.