Investigating immune cell roles in endometrial inflammation related to infertility
Official title: Lymphocyte function in inflammatory disorders of human endometrium and decidua
Funded at University of California, San Francisco · NIH-11095870 · Data updated 2026-11-12
This study is looking at how certain immune cells in the uterus might cause inflammation that can lead to fertility problems like endometriosis and PCOS, and it aims to find ways to help improve fertility for those affected.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project start | August 1, 2023 |
| Project end | April 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $615,705 |
| NIH project number | 5P50HD112034-03 |
| Project ID | NIH-11095870 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are women experiencing infertility related to endometriosis or PCOS.
✕Less likely to help
Patients without endometrial inflammation or those not experiencing infertility may not benefit from this research.
What this research studies
This research focuses on understanding how immune cells, particularly T and B lymphocytes, contribute to inflammation in the endometrium, which can lead to infertility issues such as endometriosis and polycystic ovary syndrome (PCOS). By examining the characteristics and behaviors of these immune cells throughout the menstrual cycle and during early pregnancy, the study aims to uncover the mechanisms behind chronic inflammation that affects reproductive outcomes. The approach includes detailed analysis of immune cell frequencies, genetic profiles, and their responses to specific antigens. This research could provide insights into potential therapeutic targets for improving fertility in affected patients.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve reproductive outcomes for women suffering from infertility due to endometrial inflammation.
How similar studies have gone: While the specific focus on endometrial immune cells is relatively novel, similar research has shown promise in understanding immune roles in other inflammatory conditions.
Where this research is happening
-
University of California, San Francisco
San Francisco, United States Active
Researchers
- Principal investigator: Huddleston, Heather G — University of California, San Francisco
- Study coordinator: Huddleston, Heather G
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.