Investigating immune cell behavior to find markers for breast cancer progression
Studying macrophage polarization in search for predictive and prognostic markers of breast cancer
This study is looking at a common type of breast cancer called ductal carcinoma in situ (DCIS) to find out how certain immune cells in the tumor might help predict if the cancer will become more serious, which could lead to better treatment options and avoid unnecessary procedures for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project ID | NIH-11132450 on NIH RePORTER |
What this research studies
This research focuses on ductal carcinoma in situ (DCIS), the most common form of breast cancer, to identify markers that can predict whether it will progress to invasive disease. By studying macrophages, a type of immune cell present in the tumor microenvironment, the research aims to uncover how these cells influence cancer progression. The approach involves analyzing archival tissue specimens to understand the relationship between different macrophage subtypes and patient outcomes. This could help in developing strategies to prevent unnecessary treatments for patients diagnosed with DCIS.
Who could benefit from this research
Good fit: Ideal candidates for this research are women diagnosed with ductal carcinoma in situ (DCIS).
Not a fit: Patients with invasive breast cancer or other unrelated cancers may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better predictive markers for breast cancer progression, potentially reducing overtreatment for many patients.
How similar studies have performed: Previous research has shown promise in understanding the role of immune cells in cancer progression, indicating that this approach could yield valuable insights.
Where this research is happening
Stanford, United States
- Stanford University — Stanford, United States (Active)
Researchers
- Principal investigator: Van de Rijn, Jan Matt — Stanford University
- Study coordinator: Van de Rijn, Jan Matt
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.