Investigating immune and metabolic changes in older adults
Immune and metabolic dysfunction during aging in human cohorts
This study is looking at how getting older affects the immune system and metabolism in older adults, especially those with type 2 diabetes and lung infections, to find early signs of changes and improve ways to prevent and treat health issues as we age.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Sci Ctr Houston NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-10848355 on NIH RePORTER |
What this research studies
This research focuses on understanding how aging affects immune and metabolic functions in older adults, particularly those with conditions like type 2 diabetes and lung infections. By studying a specific Hispanic cohort, the research aims to identify early signs of these changes and their underlying mechanisms, particularly the role of oxidative stress. The approach includes both snapshot and longitudinal studies, utilizing blood samples to monitor immune responses and metabolic health over time. The goal is to uncover critical pathways that could lead to better prevention and treatment strategies for age-related health issues.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults aged 65 and above, particularly those with metabolic conditions like diabetes or a history of lung infections.
Not a fit: Patients under 21 years old or those without age-related metabolic or immune issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing and managing age-related diseases, enhancing the quality of life for older adults.
How similar studies have performed: Previous research has shown promising results in understanding immune and metabolic dysfunctions in aging populations, suggesting that this approach could yield valuable insights.
Where this research is happening
Houston, United States
- University of Texas Hlth Sci Ctr Houston — Houston, United States (Active)
Researchers
- Principal investigator: Restrepo, Blanca I — University of Texas Hlth Sci Ctr Houston
- Study coordinator: Restrepo, Blanca I
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.