Investigating immune and fibrotic pathways in morphea patients
Ancillary studies to define dysregulated immune and fibrotic pathways in a well-characterized morphea cohort
['FUNDING_R01'] · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · NIH-10763425
This study is looking into morphea, a skin condition that causes hardening and thinning of the skin, to better understand how it affects the immune system and to find new ways to treat it for people who have this condition.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF PITTSBURGH AT PITTSBURGH (nih funded) |
| Locations | 1 site (PITTSBURGH, UNITED STATES) |
| Trial ID | NIH-10763425 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding morphea, a debilitating autoimmune skin disease that leads to tissue fibrosis and atrophy. By examining the immune response and gene expression in patients, the study aims to identify the specific cell populations and pathways involved in the disease's progression. Utilizing data from large registries, the research employs advanced techniques like protein assays and RNA sequencing to uncover the underlying mechanisms of morphea. The ultimate goal is to pave the way for more effective and targeted treatments for patients suffering from this condition.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with morphea, including both adults and children.
Not a fit: Patients with other skin disorders or those not diagnosed with morphea may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of more effective therapies for morphea, improving patient outcomes and quality of life.
How similar studies have performed: Previous research has shown promise in understanding autoimmune diseases through similar methodologies, indicating potential for success in this area.
Where this research is happening
PITTSBURGH, UNITED STATES
- UNIVERSITY OF PITTSBURGH AT PITTSBURGH — PITTSBURGH, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: TOROK, KATHRYN S. — UNIVERSITY OF PITTSBURGH AT PITTSBURGH
- Study coordinator: TOROK, KATHRYN S.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: skin disorder, Cutaneous Disorder, Skin Diseases, Skin Diseases and Manifestations, cutaneous disease