Investigating if tiny air particles can enter the brain and lead to Alzheimer's disease.
Do Atmospheric Ultrafine Particles Lodge in the Brain and Cause Cognitive Decline Leading to Alzheimer's Disease Related Dementias?
This study is looking at whether tiny particles from air pollution might affect brain health and increase the risk of memory problems and Alzheimer's disease, and it's for anyone interested in how our environment can impact our thinking as we age.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California at Davis NIH-funded |
| Lab location | 1 site (Davis, United States) |
| Project ID | NIH-10591354 on NIH RePORTER |
What this research studies
This research explores the potential link between exposure to ultrafine particulate matter (UFPM) from air pollution and the risk of cognitive decline and Alzheimer's disease. By studying both human participants and animal models, the researchers aim to determine if these tiny particles can cross into the brain and contribute to neurological damage. The study will utilize data from the UC Davis Alzheimer’s Disease Research Center to analyze cognitive changes in individuals living in areas with varying levels of air pollution. This approach aims to provide insights into how environmental factors may influence brain health over time.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals living in areas with high levels of air pollution, particularly those concerned about cognitive health.
Not a fit: Patients who do not reside in polluted areas or those without concerns about cognitive decline may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or mitigating cognitive decline associated with Alzheimer's disease.
How similar studies have performed: While previous studies have focused on larger particulate matter, this research is pioneering in its specific investigation of ultrafine particles and their direct effects on Alzheimer's disease.
Where this research is happening
Davis, United States
- University of California at Davis — Davis, United States (Active)
Researchers
- Principal investigator: Lein, Pamela J — University of California at Davis
- Study coordinator: Lein, Pamela J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.