NIH-funded research R21 grant

Investigating if E4orf1 can stop Alzheimer's disease from getting worse in older mice

Official title: Does E4orf1 prevent further deterioration in Alzheimer's disease pathology in older mice

Funded at Texas Tech University · NIH-10491189 · Data updated 2026-11-12

This study is looking at a protein called E4orf1 to see if it can help stop Alzheimer's disease from getting worse in older mice, and it hopes to find new ways to treat the disease by understanding how Alzheimer's and Type 2 Diabetes are connected.

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Quick facts

Grant typeR21 grant
Study typeNIH-funded research
Funding institutionTexas Tech University
NIH-funded
Lab location1 site (Lubbock, United States)
Project startSeptember 30, 2021
Project endJune 30, 2025
Funding year2022
Award (this year)$224,407
NIH project number5R21AG068940-02
Project IDNIH-10491189 on NIH RePORTER

Who could benefit from this research

Could help

Ideal candidates for this research are older adults experiencing early signs of Alzheimer's disease or those at risk due to related conditions like Type 2 Diabetes.

Less likely to help

Patients with advanced Alzheimer's disease or those without any cognitive decline may not benefit from this research.

What this research studies

This research explores the potential of E4orf1, a protein, to prevent the worsening of Alzheimer's disease in older mice. By examining the relationship between Alzheimer's and Type 2 Diabetes, the study aims to uncover shared mechanisms that could lead to effective treatment strategies. The approach involves analyzing how E4orf1 interacts with molecular pathways involved in Alzheimer's progression. If successful, this research could pave the way for new therapies that might slow down or halt the disease's advancement.

Why it matters

Potential benefit: If successful, this research could lead to new treatments that slow the progression of Alzheimer's disease.

How similar studies have gone: Previous research has shown promise in using anti-diabetic medications to improve cognitive function, indicating potential for success in this area.

Where this research is happening

  • Texas Tech University
    Lubbock, United States
    Active

Researchers

  • Principal investigator: Hegde, Vijay Karkal — Texas Tech University
  • Study coordinator: Hegde, Vijay Karkal

Related research

Other NIH-funded projects on the same topics.

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.