Investigating if a statin can prevent dementia in older adults
PREVENTABLE Administrative and Trial Management
['FUNDING_OTHER'] · DUKE UNIVERSITY · NIH-10913406
This study is looking at whether a moderate-intensity statin can help prevent dementia, especially Alzheimer's, in people aged 75 and older who don’t have heart disease, and it includes those with some health challenges to see if the medication can help them live longer without disabilities.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | DUKE UNIVERSITY (nih funded) |
| Locations | 1 site (DURHAM, UNITED STATES) |
| Trial ID | NIH-10913406 on ClinicalTrials.gov |
What this research studies
This research focuses on the PREVENTABLE trial, which aims to evaluate the effectiveness of a moderate-intensity statin in preventing dementia, particularly Alzheimer's disease, in individuals aged 75 and older who do not have clinically evident coronary heart disease. The trial will include participants with various health conditions, such as frailty and mild cognitive impairment, to assess how the statin may prolong disability-free survival. The study will be conducted by the Duke Clinical Research Institute and Wake Forest School of Medicine, leveraging their expertise and resources to ensure a comprehensive approach to patient care and data collection.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults aged 75 and above who are at risk for dementia but do not have evident coronary heart disease.
Not a fit: Patients who are younger than 75 or those with clinically evident coronary heart disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new preventive strategies for dementia, improving the quality of life for older adults.
How similar studies have performed: Previous research has shown promise in using statins for various health benefits, but this specific approach to preventing dementia is relatively novel.
Where this research is happening
DURHAM, UNITED STATES
- DUKE UNIVERSITY — DURHAM, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ALEXANDER, KAREN P — DUKE UNIVERSITY
- Study coordinator: ALEXANDER, KAREN P
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia, Alzheimer syndrome, Alzheimer's Disease, Alzheimer's disease and related dementia, Alzheimer's disease and related disorders