Investigating if a moderate-intensity statin can prevent dementia in older adults
PREVENTABLE Clinical Sites Core
This study is looking for older adults aged 75 and up, who don’t have dementia or heart disease, to see if taking a moderate-intensity statin can help prevent dementia, including Alzheimer's, while keeping track of their brain health and well-being over time.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project ID | NIH-10913416 on NIH RePORTER |
What this research studies
This research involves a collaboration between the National Patient-Centered Research Network and the VA network, focusing on older adults without dementia or cardiovascular disease. Approximately 20,000 participants aged 75 and older will be randomly assigned to receive a moderate-intensity statin to assess its effectiveness in preventing dementia, including Alzheimer's disease. The study aims to include a diverse demographic from various healthcare systems and VA hospitals across the U.S., ensuring representation from both urban and rural areas. Participants will be monitored for their cognitive health and overall well-being over time.
Who could benefit from this research
Good fit: Ideal candidates are older adults aged 75 and above who do not have dementia or cardiovascular disease.
Not a fit: Patients who already have clinically evident dementia or significant cardiovascular disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new preventive strategies for dementia, potentially improving the quality of life for older adults.
How similar studies have performed: Previous research has shown promise in using statins for cognitive health, but this specific approach in preventing dementia is novel and untested.
Where this research is happening
Durham, United States
- Duke University — Durham, United States (Active)
Researchers
- Principal investigator: Hernandez, Adrian — Duke University
- Study coordinator: Hernandez, Adrian
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.