Investigating human cancers using humanized mouse models
Official title: PDX Core
Funded at University of Pennsylvania · NIH-10881939 · Data updated 2026-11-12
This study is looking at how human cancer behaves and responds to treatments by using special mice that have human tissues, which helps researchers find better ways to fight cancer.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | July 5, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $218,828 |
| NIH project number | 5U54CA283759-02 |
| Project ID | NIH-10881939 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research are individuals with various types of cancers who may contribute human tissue samples for study.
✕Less likely to help
Patients with conditions unrelated to cancer or those who cannot provide tissue samples may not benefit from this research.
What this research studies
The PDX Core at the University of Pennsylvania focuses on advancing cancer research through the use of humanized mouse models. These models are created by transplanting human tissues into specially designed immunocompromised mice, allowing researchers to study human cancer behavior and treatment responses in a controlled environment. The research aims to improve the understanding of how human tissues function and interact in these models, which is crucial for developing effective cancer therapies. By addressing the challenges of infections and tissue engraftment, this research seeks to enhance the reliability of experimental outcomes.
Why it matters
Potential benefit: If successful, this research could lead to more effective cancer treatments tailored to human biology.
How similar studies have gone: Previous research using humanized mouse models has shown promise in understanding cancer biology and improving treatment strategies.
Where this research is happening
-
University of Pennsylvania
Philadelphia, United States Active
Researchers
- Principal investigator: Skuli, Nicolas — University of Pennsylvania
- Study coordinator: Skuli, Nicolas
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.