Investigating human cancers using humanized mouse models
PDX Core
['FUNDING_OTHER'] · UNIVERSITY OF PENNSYLVANIA · NIH-10881939
This study is looking at how human cancer behaves and responds to treatments by using special mice that have human tissues, which helps researchers find better ways to fight cancer.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF PENNSYLVANIA (nih funded) |
| Locations | 1 site (PHILADELPHIA, UNITED STATES) |
| Trial ID | NIH-10881939 on ClinicalTrials.gov |
What this research studies
The PDX Core at the University of Pennsylvania focuses on advancing cancer research through the use of humanized mouse models. These models are created by transplanting human tissues into specially designed immunocompromised mice, allowing researchers to study human cancer behavior and treatment responses in a controlled environment. The research aims to improve the understanding of how human tissues function and interact in these models, which is crucial for developing effective cancer therapies. By addressing the challenges of infections and tissue engraftment, this research seeks to enhance the reliability of experimental outcomes.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research are individuals with various types of cancers who may contribute human tissue samples for study.
Not a fit: Patients with conditions unrelated to cancer or those who cannot provide tissue samples may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective cancer treatments tailored to human biology.
How similar studies have performed: Previous research using humanized mouse models has shown promise in understanding cancer biology and improving treatment strategies.
Where this research is happening
PHILADELPHIA, UNITED STATES
- UNIVERSITY OF PENNSYLVANIA — PHILADELPHIA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SKULI, NICOLAS — UNIVERSITY OF PENNSYLVANIA
- Study coordinator: SKULI, NICOLAS
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.