Investigating how Znf740 affects CD8+ T cell function in cancer treatment
Official title: Znf740 in the regulation of CD8+T cell exhaustion
Funded at Ut Southwestern Medical Center · NIH-10906872 · Data updated 2026-11-12
This study is looking at how a protein called Znf740 helps CD8+ T cells, which are important for fighting cancer, work better in treatments like CAR-T cell therapy, with the hope of finding new ways to make these therapies more effective for cancer patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $534,291 |
| NIH project number | 5R01CA282143-02 |
| Project ID | NIH-10906872 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients with solid tumors who are undergoing or considering CAR-T cell therapy.
✕Less likely to help
Patients with hematological cancers or those who are not candidates for CAR-T cell therapy may not benefit from this research.
What this research studies
This research focuses on understanding the role of Znf740, a transcription factor, in regulating the function of CD8+ T cells, which are crucial for effective cancer treatment, particularly in CAR-T cell therapy. The study aims to explore how Znf740 influences the balance between active and exhausted CD8+ T cells in the tumor microenvironment. By using genetically modified mice, researchers will investigate the mechanisms by which Znf740 enhances the anti-tumor response of these immune cells. The ultimate goal is to identify potential therapeutic targets to improve the efficacy of CAR-T cell therapy for cancer patients.
Why it matters
Potential benefit: If successful, this research could lead to improved CAR-T cell therapies that enhance the immune response against tumors, potentially leading to better outcomes for cancer patients.
How similar studies have gone: Previous research has shown promising results in enhancing T cell function through various mechanisms, suggesting that targeting Znf740 could be a novel and potentially effective approach.
Where this research is happening
-
Ut Southwestern Medical Center
Dallas, United States Active
Researchers
- Principal investigator: Poojary, Venuprasad K — Ut Southwestern Medical Center
- Study coordinator: Poojary, Venuprasad K
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.