Investigating how zinc transport affects the spread of pancreatic cancer
Role of Zinc Dependent EMT-Transcription Factors (EMT-TF) in Pancreatic Cancer Metastasis
This study is looking at how a protein called ZIP4 affects the spread of pancreatic cancer by influencing another protein, ZEB1, and it aims to find new ways to help treat patients with this type of cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Oklahoma Hlth Sciences Ctr NIH-funded |
| Lab location | 1 site (Oklahoma City, United States) |
| Project ID | NIH-10852823 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of a zinc transporter, ZIP4, and its effect on a transcription factor called ZEB1 in the metastasis of pancreatic cancer. By exploring how ZIP4 influences cancer cell behavior, including their ability to adhere, migrate, and invade other tissues, the study aims to uncover new molecular markers and therapeutic targets. The research employs various biological assays to analyze the mechanisms at play, which could lead to improved treatment strategies for patients with pancreatic cancer.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with pancreatic cancer, particularly those experiencing metastasis or drug resistance.
Not a fit: Patients with early-stage pancreatic cancer that has not metastasized may not benefit directly from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for pancreatic cancer, potentially improving survival rates and reducing drug resistance.
How similar studies have performed: Other research has shown promise in targeting molecular pathways in cancer treatment, suggesting that this approach could yield significant insights.
Where this research is happening
Oklahoma City, United States
- University of Oklahoma Hlth Sciences Ctr — Oklahoma City, United States (Active)
Researchers
- Principal investigator: Li, Min — University of Oklahoma Hlth Sciences Ctr
- Study coordinator: Li, Min
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.