Investigating how zinc affects aging lung cells and fibrosis
ZIP8-dependent Zinc Metabolic Regulation in Alveolar Progenitor Cell Aging and Fibrosis
This study is looking at how aging affects important lung cells that help keep your lungs healthy, especially in older adults, and it aims to find ways to improve these cells' function by understanding how zinc affects them.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cedars-Sinai Medical Center NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-11083022 on NIH RePORTER |
What this research studies
This research focuses on understanding the aging process of lung cells, specifically type 2 alveolar epithelial cells (AEC2s), which are crucial for lung repair and maintenance. As people age, these cells become less effective, leading to conditions like idiopathic pulmonary fibrosis (IPF). The study aims to uncover the molecular mechanisms behind this decline and explore potential interventions to rejuvenate these cells. By examining how zinc metabolism influences AEC2 function, the research seeks to develop strategies to improve lung health in older adults.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals aged 65 and older who may be experiencing lung health issues or are at risk for age-related lung diseases.
Not a fit: Patients under the age of 65 or those without any lung health concerns may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance lung regeneration and health in older adults, potentially reducing the incidence of age-related lung diseases.
How similar studies have performed: Previous research has shown promising results in understanding lung aging and potential interventions, indicating that this approach may lead to significant advancements in treatment.
Where this research is happening
Los Angeles, United States
- Cedars-Sinai Medical Center — Los Angeles, United States (Active)
Researchers
- Principal investigator: Liang, Carol Jiurong — Cedars-Sinai Medical Center
- Study coordinator: Liang, Carol Jiurong
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.