Investigating how zinc accumulation in mitochondria contributes to brain cell death during ischemia.
Mitochondrial Zn2+ accumulation and the induction of ischemic neurodegeneration
['FUNDING_R01'] · UNIVERSITY OF CALIFORNIA-IRVINE · NIH-11010384
This study is looking at how zinc can harm brain cells during events like strokes or long seizures, and it aims to find ways to protect those cells from damage, which could help people who experience these conditions.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA-IRVINE (nih funded) |
| Locations | 1 site (IRVINE, UNITED STATES) |
| Trial ID | NIH-11010384 on ClinicalTrials.gov |
What this research studies
This research explores the role of zinc ions in causing brain cell death during ischemic events, such as strokes or prolonged seizures. By studying brain tissue samples, the researchers aim to understand how zinc accumulates in neurons and disrupts mitochondrial function, leading to cell injury. The project utilizes advanced techniques to measure changes in zinc and calcium levels in brain cells under conditions that mimic ischemia. The findings could provide insights into new therapeutic strategies to protect brain cells from damage.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults who are at risk for ischemic brain injuries, such as those with a history of strokes or seizures.
Not a fit: Patients who do not have ischemic conditions or are not part of the aging population may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that protect brain cells from damage during ischemic events, potentially improving outcomes for patients with stroke or similar conditions.
How similar studies have performed: Previous studies have shown that targeting zinc accumulation can be protective in models of brain injury, suggesting that this approach may be promising.
Where this research is happening
IRVINE, UNITED STATES
- UNIVERSITY OF CALIFORNIA-IRVINE — IRVINE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WEISS, JOHN H — UNIVERSITY OF CALIFORNIA-IRVINE
- Study coordinator: WEISS, JOHN H
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.