Investigating how ZEB2 affects the formation of neural crest cells and related facial conditions
Official title: The role of the transcriptional repressor ZEB2 in human neural crest cell formation and craniofacial pathology
Funded at State University of New York at Buffalo · NIH-11140667 · Data updated 2026-11-12
This study is looking at how a protein called ZEB2 affects the development of cells that help form the face, which could help us understand and improve treatments for people with facial differences, especially those with Mowat-Wilson Syndrome.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | State University of New York at Buffalo NIH-funded |
| Lab location | 1 site (Amherst, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $248,999 |
| NIH project number | 4R00DE029878-04 |
| Project ID | NIH-11140667 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with Mowat-Wilson Syndrome or other craniofacial abnormalities linked to neural crest cell development.
✕Less likely to help
Patients without craniofacial abnormalities or those not affected by neural crest cell-related conditions may not benefit from this research.
What this research studies
This research focuses on understanding the role of the ZEB2 protein in the development of neural crest cells, which are crucial for forming various facial structures and tissues. By studying how ZEB2 influences these cells, researchers aim to uncover the mechanisms behind craniofacial abnormalities, particularly in conditions like Mowat-Wilson Syndrome. The approach involves advanced techniques such as ATAC sequencing to analyze gene regulation and cellular behavior in human models. Patients with craniofacial defects may benefit from insights gained through this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and potential treatments for craniofacial abnormalities and related syndromes.
How similar studies have gone: Previous research has shown promising results in understanding the role of transcription factors in developmental disorders, suggesting that this approach could yield valuable insights.
Where this research is happening
-
State University of New York at Buffalo
Amherst, United States Active
Researchers
- Principal investigator: Charney, Rebekah — State University of New York at Buffalo
- Study coordinator: Charney, Rebekah
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.