Investigating how ZBP1 activation affects immune responses and cell death
ZBP1 activation
['FUNDING_R01'] · UNIVERSITY OF WASHINGTON · NIH-11006279
This study is looking at how a protein called ZBP1 can cause cell death and immune reactions, even when there’s no virus present, which might help us understand autoimmune diseases better and find new ways to treat them.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF WASHINGTON (nih funded) |
| Locations | 1 site (SEATTLE, UNITED STATES) |
| Trial ID | NIH-11006279 on ClinicalTrials.gov |
What this research studies
This research explores the role of ZBP1, a nucleotide sensor, in triggering cell death and immune responses against viral infections. It examines how ZBP1 can become activated even in the absence of infections, potentially leading to autoimmune conditions. The study utilizes genetic models to understand the interaction between ZBP1 and another protein, ADAR1, which is crucial for regulating immune responses. By investigating these mechanisms, the research aims to uncover new insights into the treatment of autoimmune diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with autoimmune diseases, particularly those related to ADAR1 mutations, such as Aicardi-Goutieres syndrome.
Not a fit: Patients with autoimmune conditions not related to ADAR1 or ZBP1 pathways may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for managing autoimmune diseases and improving antiviral immunity.
How similar studies have performed: Previous research has shown promising results in understanding the roles of nucleotide sensors in immune responses, suggesting that this approach could yield significant insights.
Where this research is happening
SEATTLE, UNITED STATES
- UNIVERSITY OF WASHINGTON — SEATTLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: OBERST, ANDREW ATWELL — UNIVERSITY OF WASHINGTON
- Study coordinator: OBERST, ANDREW ATWELL
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Aicardi Goutieres syndrome