Investigating how young blood factors can rejuvenate the aging brain
Mechanisms of youth-associated blood-borne factors regulating CNS rejuvenation
['FUNDING_R01'] · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · NIH-11080373
This study is looking at how certain things in young blood might help improve brain function in older people, especially those with Alzheimer's, by testing it on older mice to see if it can boost their thinking and memory skills.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-11080373 on ClinicalTrials.gov |
What this research studies
This research explores the potential of factors found in young blood to restore brain function in older individuals, particularly in relation to Alzheimer's disease (AD). By studying aged mice that receive young blood through methods like parabiosis or plasma injections, the researchers aim to understand how these factors can enhance neural plasticity and cognitive performance. The project focuses on identifying specific proteins that may help revitalize brain function and examining how age-related changes in the blood can affect brain health.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults experiencing cognitive decline or at risk for Alzheimer's disease.
Not a fit: Patients with early-stage Alzheimer's disease or those with other forms of dementia unrelated to age may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve cognitive function and slow the progression of Alzheimer's disease in older adults.
How similar studies have performed: Previous studies have shown promising results in rejuvenating brain function through young blood factors, indicating a potential breakthrough in understanding age-related cognitive decline.
Where this research is happening
NEW YORK, UNITED STATES
- ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CASTELLANO, JOSEPH MICHAEL — ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
- Study coordinator: CASTELLANO, JOSEPH MICHAEL
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: age associated disease, age associated disorder