Investigating how YAP/TAZ signaling affects vocal fold health
Official title: YAP/TAZ-TEAD signaling in the vocal fold
Funded at New York University School of Medicine · NIH-10810968 · Data updated 2026-11-12
This study is looking at how certain signals in the body affect scarring in the vocal folds, which can cause voice problems, and it hopes to find new ways to help improve voice health for people who struggle with these issues.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University School of Medicine NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | September 25, 2023 |
| Project end | August 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $466,125 |
| NIH project number | 1R21DC020993-01A1 |
| Project ID | NIH-10810968 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals experiencing voice disorders, particularly those with vocal fold fibrosis.
✕Less likely to help
Patients with voice disorders not related to fibrosis or those with other underlying health issues may not benefit from this research.
What this research studies
This research focuses on understanding the role of YAP/TAZ signaling in vocal fold fibrosis, a condition that leads to voice disorders affecting millions of people. By exploring the biochemical pathways involved, particularly the Hippo signaling pathway, the study aims to identify potential therapeutic targets for improving voice health. The approach includes examining how these signaling mechanisms influence cell survival and tissue growth in the vocal folds. Patients may benefit from insights that could lead to more effective treatments for voice disorders.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that significantly improve treatment options for individuals suffering from voice disorders.
How similar studies have gone: Previous research has shown promise in targeting similar signaling pathways for treating fibrosis, suggesting potential for success in this approach.
Where this research is happening
-
New York University School of Medicine
New York, United States Active
Researchers
- Principal investigator: Nakamura, Ryosuke — New York University School of Medicine
- Study coordinator: Nakamura, Ryosuke
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.