Investigating how YAP/TAZ proteins affect kidney cancer
The Oncogenic functions of YAP/TAZ in Renal Cell Carcinoma
['FUNDING_FELLOWSHIP'] · GEORGETOWN UNIVERSITY · NIH-11061291
This study is looking at how certain proteins called YAP and TAZ affect kidney cancer and hopes to find out if blocking them can change how cancer cells behave, which could help develop new treatments for people with kidney cancer.
Quick facts
| Phase | ['FUNDING_FELLOWSHIP'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | GEORGETOWN UNIVERSITY (nih funded) |
| Locations | 1 site (WASHINGTON, UNITED STATES) |
| Trial ID | NIH-11061291 on ClinicalTrials.gov |
What this research studies
This research focuses on renal cell carcinoma (RCC), a common and deadly form of kidney cancer. The study aims to understand the role of YAP/TAZ proteins in cancer progression by examining how their inhibition can alter cancer cell behavior. Using advanced techniques, researchers will analyze patient-derived cells to see how blocking these proteins affects cancer-related gene activity and the overall cancer environment. This could lead to new treatment strategies for patients with RCC.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults diagnosed with renal cell carcinoma, particularly those with advanced or metastatic disease.
Not a fit: Patients with early-stage renal cell carcinoma or those with other types of cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective therapies for patients suffering from renal cell carcinoma.
How similar studies have performed: Other research has shown promising results in targeting similar oncogenic pathways, suggesting that this approach could be effective.
Where this research is happening
WASHINGTON, UNITED STATES
- GEORGETOWN UNIVERSITY — WASHINGTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MCINTOSH, ALEC THOMAS — GEORGETOWN UNIVERSITY
- Study coordinator: MCINTOSH, ALEC THOMAS
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: cancer microenvironment, Cancers