Investigating how YAP signaling affects liver disease in people with HIV
YAP signaling in the pathogenesis of NAFLD in people living with HIV
['FUNDING_R01'] · MASSACHUSETTS GENERAL HOSPITAL · NIH-10931742
This study is looking at how a specific signaling process in the liver affects people with HIV who have nonalcoholic fatty liver disease, with the goal of finding new ways to help improve liver health for those living with this condition.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MASSACHUSETTS GENERAL HOSPITAL (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-10931742 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the role of YAP signaling in the development of nonalcoholic fatty liver disease (NAFLD) among individuals living with HIV. It aims to explore the mechanisms behind the high prevalence of liver disease in this population, particularly how HIV influences liver fibrosis and inflammation. By studying the Hippo signaling pathway and its impact on liver cells, the research seeks to identify potential therapeutic targets that could improve liver health in patients with HIV. The approach includes both human studies and animal models to validate findings.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults living with HIV who are experiencing or at risk for nonalcoholic fatty liver disease.
Not a fit: Patients who do not have HIV or those without liver disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that significantly improve liver health and reduce complications for people living with HIV.
How similar studies have performed: Previous research has shown promising results in understanding liver disease mechanisms in HIV, but this specific approach focusing on YAP signaling is relatively novel.
Where this research is happening
BOSTON, UNITED STATES
- MASSACHUSETTS GENERAL HOSPITAL — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CHUNG, RAYMOND T — MASSACHUSETTS GENERAL HOSPITAL
- Study coordinator: CHUNG, RAYMOND T
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired Immune Deficiency Syndrome Virus, Acquired Immunodeficiency Syndrome Virus