Investigating how YAP signaling affects liver disease in people with HIV
Official title: YAP signaling in the pathogenesis of NAFLD in people living with HIV
Funded at Massachusetts General Hospital · NIH-10931742 · Data updated 2026-11-12
This study is looking at how a specific signaling process in the liver affects people with HIV who have nonalcoholic fatty liver disease, with the goal of finding new ways to help improve liver health for those living with this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | September 26, 2023 |
| Project end | July 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $780,234 |
| NIH project number | 5R01DK138474-02 |
| Project ID | NIH-10931742 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults living with HIV who are experiencing or at risk for nonalcoholic fatty liver disease.
✕Less likely to help
Patients who do not have HIV or those without liver disease may not benefit from this research.
What this research studies
This research focuses on understanding the role of YAP signaling in the development of nonalcoholic fatty liver disease (NAFLD) among individuals living with HIV. It aims to explore the mechanisms behind the high prevalence of liver disease in this population, particularly how HIV influences liver fibrosis and inflammation. By studying the Hippo signaling pathway and its impact on liver cells, the research seeks to identify potential therapeutic targets that could improve liver health in patients with HIV. The approach includes both human studies and animal models to validate findings.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that significantly improve liver health and reduce complications for people living with HIV.
How similar studies have gone: Previous research has shown promising results in understanding liver disease mechanisms in HIV, but this specific approach focusing on YAP signaling is relatively novel.
Where this research is happening
-
Massachusetts General Hospital
Boston, United States Active
Researchers
- Principal investigator: Chung, Raymond T — Massachusetts General Hospital
- Study coordinator: Chung, Raymond T
Related research
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Small blood particle signals and fatty liver in children and teens
Researchers are looking at whether molecules carried in tiny blood particles can explain or signal fatty liver disease in children and adolescents with excess weight.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.