Investigating how XPO1 affects the export of RNA from the cell nucleus
Official title: The role of XPO1 in nuclear export of RNA
Funded at University of Miami School of Medicine · NIH-10899544 · Data updated 2026-11-12
This study is looking at a protein called XPO1 that helps move RNA in our cells, and it's for anyone interested in how changes in this protein might affect diseases related to RNA processing, which could help improve understanding and treatment options.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Miami School of Medicine NIH-funded |
| Lab location | 1 site (Coral Gables, United States) |
| Project start | August 15, 2023 |
| Project end | July 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $383,750 |
| NIH project number | 5R35GM151109-02 |
| Project ID | NIH-10899544 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with genetic mutations affecting RNA processing or related diseases.
✕Less likely to help
Patients with conditions unrelated to RNA export or XPO1 function may not benefit from this research.
What this research studies
This research focuses on understanding the role of XPO1, a key protein responsible for exporting RNA from the nucleus of eukaryotic cells. By using advanced techniques in molecular biology, genomics, and mouse models, the researchers aim to uncover how mutations in XPO1 can alter RNA processing and gene expression. The study will explore the interactions between XPO1 and various RNA molecules, which may have implications for diseases linked to RNA export dysfunction. Patients may benefit from insights gained into how these processes affect disease progression and treatment responses.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for diseases caused by RNA export dysfunction.
How similar studies have gone: Previous research has shown promising results in understanding the role of nuclear export proteins in various diseases, indicating that this approach has potential for success.
Where this research is happening
-
University of Miami School of Medicine
Coral Gables, United States Active
Researchers
- Principal investigator: Taylor, Justin — University of Miami School of Medicine
- Study coordinator: Taylor, Justin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.