Investigating how X-chromosomes affect Alzheimer's disease differences between sexes
Mechanisms of X-Chromosome-dependent Sex Difference inAlzheimers Disease
['FUNDING_R01'] · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · NIH-10875697
This study is looking at how having two X chromosomes might help protect women from Alzheimer's disease, and it aims to find new ways to improve treatments for everyone affected by the condition.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA, SAN FRANCISCO (nih funded) |
| Locations | 1 site (SAN FRANCISCO, UNITED STATES) |
| Trial ID | NIH-10875697 on ClinicalTrials.gov |
What this research studies
This research explores the role of X-chromosomes in influencing Alzheimer's disease (AD) by examining both mouse models and human studies. It aims to understand how biological sex differences contribute to varying vulnerabilities to AD, particularly focusing on the protective effects of having two X chromosomes in females. By integrating genetic models and analyzing the impact of sex chromosomes on disease progression, the study seeks to uncover new pathways that could lead to improved treatments for both men and women affected by AD.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals aged 65 and older, particularly those with a diagnosis of Alzheimer's disease or at risk for developing it.
Not a fit: Patients who are younger than 65 or do not have Alzheimer's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights and therapeutic strategies that improve outcomes for patients with Alzheimer's disease.
How similar studies have performed: While the specific focus on X-chromosome mechanisms in Alzheimer's is relatively novel, previous research has shown that sex differences significantly impact disease progression and outcomes in neurodegenerative conditions.
Where this research is happening
SAN FRANCISCO, UNITED STATES
- UNIVERSITY OF CALIFORNIA, SAN FRANCISCO — SAN FRANCISCO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: DUBAL, DENA BOU — UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
- Study coordinator: DUBAL, DENA BOU
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia