Investigating how Wnt/Ca2+ signaling affects triple-negative breast cancer spread and treatment resistance
Functional role of Wnt/Ca2+ signaling in triple-negative breast cancer metastasis and chemoresistance
This study is looking at how calcium signals in cells might help triple-negative breast cancer spread and resist treatment, using special mice to learn more about it, with the hope of finding better ways to treat patients like you.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor College of Medicine NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-11054431 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of calcium signaling in the spread and treatment resistance of triple-negative breast cancer (TNBC). Researchers will create a specialized mouse model that can measure calcium levels in real-time, allowing them to explore how Wnt signaling pathways influence cancer cell behavior. By identifying the mechanisms behind metastasis and drug resistance, the study aims to uncover potential new therapeutic targets for TNBC. Patients may benefit from insights that could lead to more effective treatments.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with triple-negative breast cancer, particularly those experiencing metastasis or treatment resistance.
Not a fit: Patients with non-triple-negative breast cancer types or those who have not developed metastasis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatment strategies that improve outcomes for patients with triple-negative breast cancer.
How similar studies have performed: Previous research has shown promising results in targeting calcium signaling pathways in cancer, suggesting that this approach may yield significant insights.
Where this research is happening
Houston, United States
- Baylor College of Medicine — Houston, United States (Active)
Researchers
- Principal investigator: Si, Hongjiang — Baylor College of Medicine
- Study coordinator: Si, Hongjiang
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.