Investigating how WNT signaling contributes to atrial fibrillation
Official title: WNT Signaling in the Pathogenesis of Atrial Fibrillation
Funded at Massachusetts General Hospital · NIH-10984720 · Data updated 2026-11-12
This study is looking at how certain signals in the heart might lead to atrial fibrillation, a common heart rhythm problem, using mice to find new ways to help treat it.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | August 1, 2024 |
| Project end | July 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $169,974 |
| NIH project number | 1K08HL171874-01A1 |
| Project ID | NIH-10984720 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with atrial fibrillation or those at risk of developing this condition.
✕Less likely to help
Patients without atrial fibrillation or those with other unrelated cardiac conditions may not benefit from this research.
What this research studies
This research focuses on understanding the role of WNT signaling in the development of atrial fibrillation (AF), a common heart rhythm disorder that can lead to serious complications like stroke and heart failure. The study utilizes mouse models to explore how changes in specific genes and signaling pathways contribute to AF. By examining the effects of non-canonical WNT signaling and its impact on heart function, the research aims to identify potential new therapeutic targets for treating AF.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve heart health and reduce the risks associated with atrial fibrillation.
How similar studies have gone: Previous research has shown promising results in understanding the mechanisms of atrial fibrillation, making this approach a continuation of established scientific inquiry.
Where this research is happening
-
Massachusetts General Hospital
Boston, United States Active
Researchers
- Principal investigator: Bapat, Aneesh — Massachusetts General Hospital
- Study coordinator: Bapat, Aneesh
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-
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.