Investigating how Wnt signaling affects cell organization and disease
Wnt/Frizzled-PCP signaling in development and disease
This study is looking at how certain signals in our cells help them stay organized and work properly, which is important for our organs, and it hopes to find ways to improve treatments for diseases like cancer that can happen when this organization goes wrong.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11074086 on NIH RePORTER |
What this research studies
This research explores the role of Wnt/Frizzled signaling in the polarization of epithelial cells, which is crucial for their function and organization in various organs. By examining how these signaling pathways influence cell behavior during development and in diseases, the study aims to uncover mechanisms that could lead to better understanding and treatment of conditions linked to cell polarity. The approach involves both cellular and molecular techniques to analyze the effects of Wnt signaling on cell arrangement and communication. Patients may benefit from insights gained into how disruptions in these processes contribute to diseases such as cancer.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would include individuals with conditions related to epithelial cell dysfunction, such as certain cancers.
Not a fit: Patients with conditions unrelated to epithelial cell signaling or polarity may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for diseases associated with cell polarity and organization.
How similar studies have performed: Previous research has shown success in understanding cell signaling pathways in development and disease, indicating that this approach has potential for meaningful discoveries.
Where this research is happening
New York, United States
- Icahn School of Medicine at Mount Sinai — New York, United States (Active)
Researchers
- Principal investigator: Mlodzik, Marek — Icahn School of Medicine at Mount Sinai
- Study coordinator: Mlodzik, Marek
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.