Investigating how Wnt signaling affects breast cancer spread
Official title: Wnt-driven adhesion and extracellular matrix dynamics in breast cancer metastasis
Funded at Baylor College of Medicine · NIH-10998319 · Data updated 2026-11-12
This study is looking at how certain signals in the body affect triple-negative breast cancer, especially in Hispanic and African-American women, to find better ways to treat this aggressive cancer and help patients live healthier lives.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor College of Medicine NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | December 1, 2024 |
| Project end | November 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $48,974 |
| NIH project number | 1F31CA295013-01 |
| Project ID | NIH-10998319 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are women diagnosed with triple-negative breast cancer, particularly those from Hispanic and African-American backgrounds.
✕Less likely to help
Patients with non-triple-negative breast cancer subtypes may not receive direct benefits from this research.
What this research studies
This research focuses on triple-negative breast cancer (TNBC), a particularly aggressive form of breast cancer that affects a significant number of Hispanic and African-American women. The study aims to understand how Wnt signaling pathways influence the behavior of cancer cells, particularly in their ability to invade and spread to other parts of the body. By examining the role of specific receptors and their impact on the extracellular matrix, the research seeks to uncover mechanisms that could lead to better treatment strategies for TNBC. Patients may benefit from insights gained about how to target these pathways to improve outcomes.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies that improve survival rates for patients with triple-negative breast cancer.
How similar studies have gone: Previous research has shown promising results in targeting Wnt signaling pathways in cancer treatment, suggesting potential for success in this area.
Where this research is happening
-
Baylor College of Medicine
Houston, United States Active
Researchers
- Principal investigator: Mendoza Mendoza, Erika — Baylor College of Medicine
- Study coordinator: Mendoza Mendoza, Erika
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.