Investigating how white matter changes after a stroke affect thinking skills in older adults
Official title: Post-stroke normal appearing white matter diffusion properties and cognitive trajectories across age
Funded at Northwestern University at Chicago · NIH-11014350 · Data updated 2026-11-12
This study is looking at how changes in the brain after a stroke can affect thinking skills in older adults, especially in women and Black individuals, to help us understand the risk of Alzheimer's and similar conditions, and participants will have some brain scans to track these changes over time.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northwestern University at Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project start | February 1, 2023 |
| Project end | January 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $666,679 |
| NIH project number | 5R01NS126509-03 |
| Project ID | NIH-11014350 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include older adults who have experienced a stroke and may be at risk for cognitive impairment.
✕Less likely to help
Patients who have not had a stroke or those with pre-existing severe cognitive impairment may not benefit from this research.
What this research studies
This research focuses on understanding how changes in the brain's white matter after a stroke can impact cognitive abilities, particularly in older adults. By using advanced imaging techniques, the study aims to identify specific brain changes that correlate with cognitive decline and the risk of developing Alzheimer's disease and related dementias. The research will also explore these effects in diverse populations, including women and Black individuals, who may face greater health disparities. Participants may undergo imaging tests to assess their brain's structure and function over time.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing cognitive decline in stroke survivors, particularly among older adults.
How similar studies have gone: Previous studies have shown promising results in understanding the relationship between brain structure and cognitive function, suggesting that this approach may yield valuable insights.
Where this research is happening
-
Northwestern University at Chicago
Chicago, United States Active
Researchers
- Principal investigator: Ingo, Carson J — Northwestern University at Chicago
- Study coordinator: Ingo, Carson J
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.