Investigating how weight loss affects muscle and bone health in older adults
Official title: INVESTigations of Muscle and Bone Health: Developing Automated Approaches for CT-Based Analyses
Funded at Wake Forest University Health Sciences · NIH-11140262 · Data updated 2026-11-12
This study is looking at how losing weight affects muscle and bone health in older adults with obesity, and it wants to find out if wearing a weighted vest or doing resistance training while losing weight can help keep your bones and muscles strong.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Wake Forest University Health Sciences NIH-funded |
| Lab location | 1 site (Winston-Salem, United States) |
| Project start | June 12, 2024 |
| Project end | June 11, 2027 |
| Funding year | 2025 |
| Award (this year) | $48,974 |
| NIH project number | 5F31AG086010-02 |
| Project ID | NIH-11140262 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults living with obesity who are concerned about weight loss and its effects on their muscle and bone health.
✕Less likely to help
Patients who are not older adults or who do not have obesity may not receive benefit from this research.
What this research studies
This research focuses on understanding the impact of weight loss on muscle and bone health in older adults, particularly those living with obesity. It compares the effects of weight loss alone to weight loss combined with the use of a weighted vest or resistance training on bone health indicators. The study utilizes advanced CT imaging to analyze changes in muscle and bone density over a 12-month period. By exploring these different approaches, the research aims to identify safer weight loss strategies that minimize the risk of muscle and bone loss.
Why it matters
Potential benefit: If successful, this research could lead to safer weight loss interventions for older adults that help preserve muscle and bone health.
How similar studies have gone: Previous research has shown that resistance training can mitigate bone loss during weight loss, suggesting that this study's approach may yield valuable insights.
Where this research is happening
-
Wake Forest University Health Sciences
Winston-Salem, United States Active
Researchers
- Principal investigator: Lynch, Delanie — Wake Forest University Health Sciences
- Study coordinator: Lynch, Delanie
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.