Investigating how vitamin D affects inflammation and smell loss in chronic rhinosinusitis
Official title: Vitamin D as a modulator of inflammation in CRS-related olfactory loss
Funded at University of Florida · NIH-11122743 · Data updated 2026-11-12
This study is looking at how vitamin D3 might help people with chronic rhinosinusitis and nasal polyps by reducing inflammation and improving their sense of smell.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project start | May 1, 2025 |
| Project end | April 30, 2030 |
| Funding year | 2025 |
| Award (this year) | $490,075 |
| NIH project number | 1R01DC022733-01 |
| Project ID | NIH-11122743 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with chronic rhinosinusitis, particularly those experiencing olfactory dysfunction.
✕Less likely to help
Patients without chronic rhinosinusitis or those who do not experience smell loss may not benefit from this research.
What this research studies
This research focuses on chronic rhinosinusitis (CRS), a condition that often leads to loss of smell, particularly in patients with nasal polyps. The study will explore the role of vitamin D3 as a potential treatment to reduce inflammation and improve olfactory function. Researchers will investigate how vitamin D3 affects immune cells involved in inflammation and how this might help restore the sense of smell in affected patients. The approach includes both observational studies and experimental models to confirm the effects of vitamin D3 on olfactory outcomes.
Why it matters
Potential benefit: If successful, this research could provide a new treatment option for patients suffering from smell loss due to chronic rhinosinusitis.
How similar studies have gone: Previous studies have shown promising results with vitamin D in reducing inflammation, but this specific approach to olfactory loss in CRS is novel.
Where this research is happening
-
University of Florida
Gainesville, United States Active
Researchers
- Principal investigator: Mulligan, Jennifer Konopa — University of Florida
- Study coordinator: Mulligan, Jennifer Konopa
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.