Investigating how vitamin A transport affects eye health
STRA6 and Ocular Vitamin A Homeostasis
This study is looking at how a protein called STRA6 helps move vitamin A in the body, which is really important for keeping our eyes healthy, and it’s for anyone interested in understanding how problems with vitamin A can lead to eye issues like night blindness.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Case Western Reserve University NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project ID | NIH-10929474 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of the STRA6 protein in the transport of vitamin A, which is crucial for maintaining vision and overall eye health. By studying mice that lack STRA6, researchers aim to uncover how disruptions in vitamin A transport can lead to various ocular diseases, including night blindness and other serious eye conditions. The study will involve examining the structural integrity of the blood-retinal barrier and the effects of vitamin A deficiency on retinal cells. This research could provide insights into potential treatments for vitamin A-related eye disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals experiencing vision problems related to vitamin A deficiency or those with specific ocular diseases.
Not a fit: Patients with ocular conditions unrelated to vitamin A transport or metabolism may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating vision loss associated with vitamin A deficiencies.
How similar studies have performed: Previous research has shown promising results in understanding vitamin A transport mechanisms, suggesting that this approach could yield valuable insights.
Where this research is happening
Cleveland, United States
- Case Western Reserve University — Cleveland, United States (Active)
Researchers
- Principal investigator: Von Lintig, Johannes Friedrich — Case Western Reserve University
- Study coordinator: Von Lintig, Johannes Friedrich
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.