Investigating how viruses acquire genes from their hosts
Molecular mechanisms and ramifications of horizontal gene transfer into poxviruses
This study is looking at how poxviruses can pick up genes from the cells they infect, which helps them survive and evolve, and it aims to find new ways to understand and treat viral infections.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California at Davis NIH-funded |
| Lab location | 1 site (Davis, United States) |
| Project ID | NIH-10756933 on NIH RePORTER |
What this research studies
This research focuses on understanding the process of horizontal gene transfer (HGT) in poxviruses, which is when viruses acquire genes from their host organisms. The researchers aim to develop experimental models to directly observe and analyze how these genes are transferred and how they contribute to the virus's evolution and survival. By using advanced cell culture techniques, they will explore the molecular mechanisms behind HGT and its implications for viral behavior. This work could lead to new insights into viral infections and potential therapeutic strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals affected by poxvirus infections or those interested in the genetic mechanisms of viral diseases.
Not a fit: Patients with non-viral infections or those not affected by poxviruses may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of viral evolution and lead to improved treatments for viral infections.
How similar studies have performed: While the concept of horizontal gene transfer in viruses has been explored, this research aims to develop novel experimental models, making it a potentially groundbreaking approach.
Where this research is happening
Davis, United States
- University of California at Davis — Davis, United States (Active)
Researchers
- Principal investigator: Rothenburg, Stefan — University of California at Davis
- Study coordinator: Rothenburg, Stefan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.