Investigating how viral noncoding RNAs affect cell transformation in lymphoid cells.
Viral Noncoding RNAs and Cell Transformation
['FUNDING_R01'] · YALE UNIVERSITY · NIH-11001137
This study is looking at how certain viruses, like Epstein-Barr, can change the behavior of immune cells and might lead to cancer, with the hope that understanding this could help find new treatments for patients.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | YALE UNIVERSITY (nih funded) |
| Locations | 1 site (NEW HAVEN, UNITED STATES) |
| Trial ID | NIH-11001137 on ClinicalTrials.gov |
What this research studies
This research explores the role of noncoding RNAs produced by oncogenic herpesviruses in transforming lymphoid cells, particularly focusing on Epstein-Barr virus, Herpesvirus saimiri, and Kaposi's sarcoma-associated herpesvirus. By studying how these viral RNAs interact with host cell processes, the research aims to uncover mechanisms that may lead to cancer development. Patients may benefit from insights gained about how these viruses influence B and T cell behavior, potentially leading to new therapeutic strategies.
Who could benefit from this research
Good fit: Ideal candidates include individuals with cancers linked to Epstein-Barr virus, Herpesvirus saimiri, or Kaposi's sarcoma-associated herpesvirus.
Not a fit: Patients without viral infections or those with cancers unrelated to the studied herpesviruses may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for cancers associated with viral infections.
How similar studies have performed: Previous research has shown promising results in understanding the role of viral noncoding RNAs in cancer, indicating that this approach has potential for significant findings.
Where this research is happening
NEW HAVEN, UNITED STATES
- YALE UNIVERSITY — NEW HAVEN, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: STEITZ, JOAN A. — YALE UNIVERSITY
- Study coordinator: STEITZ, JOAN A.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.