Investigating how viral infections affect children with tracheostomies and their microbiomes
Viral respiratory infections in a tracheostomy cohort: Microbiome-host interplay
This study is looking at children with tracheostomies who are more likely to get serious respiratory infections, to see how the germs in their airways and their immune system work together during these infections, with the hope of finding better ways to treat them.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston Children's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10883774 on NIH RePORTER |
What this research studies
This research focuses on children with tracheostomies who are at high risk for severe acute respiratory infections (ARIs). It aims to understand the interplay between the microbiome and the host's immune response during these infections. By analyzing the airway ecosystem, the study seeks to identify how changes in bacterial populations during viral infections may influence the severity of ARIs. The ultimate goal is to develop more effective treatment strategies tailored to this vulnerable population.
Who could benefit from this research
Good fit: Ideal candidates for this research are children aged 0-11 years who have a tracheostomy and are at risk for acute respiratory infections.
Not a fit: Patients who do not have a tracheostomy or are outside the age range of 0-11 years may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment options and reduced mortality rates for children with tracheostomies suffering from viral respiratory infections.
How similar studies have performed: Previous research has indicated that understanding the microbiome's role in respiratory infections can lead to significant advancements in treatment, suggesting this approach has potential for success.
Where this research is happening
Boston, United States
- Boston Children's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Mansbach, Jonathan M — Boston Children's Hospital
- Study coordinator: Mansbach, Jonathan M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.